Funding research locally

Cellular response to DNA damage

Jason ParsonsDr Jason Parsons

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool

 

The cellular response to DNA damage: Ubiquitylation-dependent regulation of 8-oxoguanine DNA glycosylase (OGG1)

Damage to the DNA in our cells is usually fixed by the body’s own repair mechanisms. A repair protein known as OGG1 plays an important part in this process, targeting DNA damage known to cause mutations and which is thought to lead to cancer. Indeed, lower protein levels of OGG1 are found in patients with head and neck cancer.

However, it’s not known how the human body regulates the amount of this particular protein within cells, and thus prevents cancer development. This research project aims to reveal the details of this process and shed new light on the role of OGG1 in the prevention and treatment of cancer.

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