Funding research locally

Cellular protein levels

Jason ParsonsDr Jason Parsons

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool

 

Molecular mechanism of regulation of the cellular protein levels of endonuclease III homologue (NTH1) in response to DNA damage

Our DNA is packaged into chromosomes that contain the genetic information required for normal daily life. However, the DNA molecule is prone to attack, creating DNA damage which can cause mutations and ultimately the development of cancer.

To prevent this, our cells contain repair mechanisms that correct the damage to the DNA. Indeed, a repair protein called NTH1 plays an important role in this process, which is demonstrated by the fact that patients with various different cancers have lower protein levels of NTH1.

Despite this, we currently do not understand how the human body controls the amount of this particular protein within our cells.

This research project will uncover the details of this process, and is important in our understanding of the function of NTH1 in the prevention of cancer, as well as identifying new cancer treatment strategies.

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